Additional Autoimmune Diseases With Type 1 Diabetes in Pediatrics at Diabetes Diagnosis and During Follow-up (AADT1D)

Central Hospital, Nancy, France

Status: Unknown

Conditions: Celiac Disease; Type 1 Diabetes; Vitiligo; Addison Disease; Graves Disease; Hashimoto Disease; Autoimmune Diseases

Treatments: Other: No intervention.

Study type: Observational

Funder types: Other

Identifiers

NCT04789993

2020PI283

Details and patient eligibility

About

This study aims to describe the prevalence of additional autoimmune diseases and their specific antibodies at type 1 diabetes (T1D) diagnosis, and their incidence rate during follow-up, for children and adolescents. It also aims to describe the characteristics of the pediatric cohort followed since 2014 for type 1 diabetes by one of France's centers of reference for paediatric diabetes.

Enrollment: 250 estimated patients

Sex: All

Ages: 6+ months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with type 1 diabetes diagnosed with the following criteria: (i) Classic symptoms of diabetes or hyperglycemic crisis, with plasma glucose concentration ≥11.1 mmol/L (200 mg/dl), or (ii) fasting plasma glucose ≥7.0 mmol/l (≥126 mg/dl) ; and (iii) presence of diabetes associated autoantibodies : ICA, GAD, IA2, IAA and/or ZnT8
• age < 18 years old at type 1 diabetes diagnostic
• type 1 diabetes diagnosed between 2014-01-01 and 2021-02-01

Exclusion criteria

• type 1 diabetes diagnostic not certain