Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis

Taipei Medical University

Status and phase: Unknown; Phase 4

Conditions: Physical Activity; Functional Performance

Treatments: Drug: Triamcinolone; Device: Hyaluronic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT02949466

MOST 105-2314-B-341-002

Details and patient eligibility

About

Using a double-blind, randomized controlled design to investigate the additional therapeutic effects of 3 times of combined triamcinolone and hyaluronic acid injections to 3 times of hyaluronic acid injections to patients with knee osteoarthritis.

Full description

A total of 56 patients will be enrolled and randomized into two groups, including 3 times of triamcinolone combined hyaluronic acid injections group and 3 times of hyaluronic acid injections group.

The triamcinolone combined hyaluronic acid injections group will receive 3 times of triamcinolone combined hyaluronic acid injection per week in three weeks; the hyaluronic acid group will receive hyaluronic acid injection in three weeks.

Physical activities and functional performance will be evaluated at before injection, at after one week, one month, three months, and six months of completion of 3 times of injections.

Enrollment: 56 estimated patients

Sex: All

Ages: 40 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• knee osteoarthritis with Kellgren/Lawrence grade II or III

Exclusion criteria

• who have neurological deficit, such as stroke who have implant in knee

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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56 participants in 2 patient groups

triamcinolone and hyaluronic acid group

Experimental group

Description:

combined triamcinolone (Triamcinolone 10 mg 1cc) and hyaluronic acid (2 cc) injections: one injection per week, for 3 weeks, to compare the additional therapeutic effects of combined triamcinolone and hyaluronic acid injections to hyaluronic acid injections

Treatment:

Drug: Triamcinolone

Device: Hyaluronic acid

hyaluronic acid group

Active Comparator group

Description:

hyaluronic acid (2cc) injection: one injection per week, for 3 weeks, to compare the additional therapeutic effects of combined triamcinolone and hyaluronic acid injections to hyaluronic acid injections

Treatment:

Device: Hyaluronic acid