Additional Effects of Vagus Nerve Stimulation on Motor Functions of Upper-limb in Stroke

Riphah International University

Status: Completed

Conditions: Stroke (CVA) or TIA

Treatments: Other: Vagus nerve stimulation with task oriented training; Other: Task oriented training

Study type: Interventional

Funder types: Other

Identifiers

NCT05771805

Irrij Javed Jadoon

Details and patient eligibility

About

The study aims to determine the additional effects of vagus nerve stimulation with task-oriented training on motor functions of upper-limb in stroke

Full description

Stroke is a clinical syndrome characterized by rapidly developing clinical signs of focal (or global) disturbance of cerebral function lasting more than 24 hours or leading to death with no apparent cause. Nerve stimulation paired with rehabilitation is a novel potential treatment option for people with long-term moderate-to-severe arm impairment after stroke. The study aims to determine the additional effects of vagus nerve stimulation with task-oriented training on motor functions of upper-limb in stroke. The idea of stimulating the vagus nerve to modify central brain activity has been pursued. Vagus nerve stimulation (VNS) paired with rehabilitative training enhances recovery of function in models of stroke and is currently under investigation for use in chronic stroke patients. Compared to traditional stimulation, noninvasive VNS seems to be safer and more tolerable.

Enrollment: 50 patients

Sex: All

Ages: 40 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sub-Acute stroke (3 months to 6 months)
• Between grade 0 and grade 2 on modified Ashworth scale.
• Patients who will be able to walk without assisted devices and can stand for 2 minutes.
• Either type Ischemic or Hemorrhagic
• Age bracket 40-60 Years

Exclusion criteria

• Previous surgical intervention on vagus nerve
• Severe pain in upper extremity
• MoCA score of less than 10

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

Vagus nerve stimulation with task oriented training

Experimental group

Description:

Vagus nerve stimulation with task oriented training

Treatment:

Other: Vagus nerve stimulation with task oriented training

Task oriented training

Active Comparator group

Description:

Task oriented training alone

Treatment:

Other: Task oriented training