Additional Metabolic and Vascular Effects of Exercise in Patients on Diet-based Weight Loss Programs

Hospital de Clinicas de Porto Alegre

Status: Unknown

Conditions: Obesity

Treatments: Behavioral: General lifestyle, diet and physical activity counselling; Behavioral: Exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT00929890

08282

Details and patient eligibility

About

This study tests the hypothesis that exercise training can confer additional benefit to patients in weight-loss programs in the form of improvements in either metabolic or vascular parameters or both. Patients will be randomized to either diet plus conventional physical activity or diet plus a planned exercise training. The interventions will be carried out until the patients lose between 5% and 7.5% of their initial weight. At entry and at the end, all subjects will be evaluated for outcomes such as blood glucose, lipid profile, insulin, c-reactive protein, fibrinogen, vascular reactivity (doppler ultrasound) and total and abdominal visceral fat (CT-scan). Both groups will be compared.

Enrollment: 50 estimated patients

Sex: All

Ages: 20 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI> 30 and <40

Exclusion criteria

• Diabetes mellitus
• Active endocrine disease
• Active heart disease
• Active smoking
• Medical contra-indications for exercise
• Using anti-obesity drugs

Trial design

50 participants in 2 patient groups

Lifestyle counseling

Active Comparator group

Description:

Patients will receive dietary counseling and a general advice on physical activity

Treatment:

Behavioral: General lifestyle, diet and physical activity counselling

Exercise training

Experimental group

Description:

patients will receive dietary counseling and will be enrolled in supervised exercise training

Treatment:

Behavioral: Exercise training