Additive Effect of Intravenous Acetaminophen on Postoperative Pain Control

Seoul National University

Status: Completed

Conditions: Postoperative Pain; Gynecologic Disease

Treatments: Drug: Acetaminophen

Study type: Interventional

Funder types: Other

Identifiers

NCT03644147

H-1807-151-961

Details and patient eligibility

About

This study aimed to evaluate the additive effect of acetaminophen on postoperative pain control in patients receiving nefopam and fentanyl-based patient-controlled analgesia.

Participants undergoing laparoscopic hysterectomy will be randomly assigned to treatment group or control group. After end of surgery, acetaminophen or normal saline (placebo) will be administered intravenously depending on the group assigned.

Enrollment: 84 patients

Sex: Female

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing total laparoscopic hysterectomy due to uterine myoma, cervical cancer, endometriosis, uterine prolapse

Exclusion criteria

• Liver disease (aspartate transaminase OR alanine transaminase > 80 IU/L)
• Chronic kidney disease (GFR < 30 ml/min/1.73m2)
• History of drug allergy
• Chronic pain lasting more than 3 months
• Conversion to laparotomy
• Complex surgery (co-operation with colon surgeon or urologist)
• Limitation in expressing pain

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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84 participants in 2 patient groups

Treatment

Experimental group

Description:

Patients in this group will receive 1 gram of acetaminophen intravenously after the end of surgery.

Treatment:

Drug: Acetaminophen

Control

No Intervention group

Description:

Patients in this group will receive 100 ml of normal saline intravenously after the end of surgery.