Additive Effects of Pravastatin and Valsartan

Gachon University Gil Medical Center

Status and phase: Completed; Phase 4

Conditions: Hypertension; High Cholesterol

Treatments: Drug: pravastatin, valsartan, pravastatin+valsartan

Study type: Interventional

Funder types: Other

Identifiers

NCT01004237

GMC-200912

Details and patient eligibility

About

The investigators hypothesize that pravastatin combined with valsartan may have additive effects in hypertensive, hypercholesterolemic patients.

Enrollment: 52 patients

Sex: All

Ages: 25 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hypertension and low-density lipoprotein cholesterol levels >100

Exclusion criteria

• Overt liver disease Chronic renal failure Hypothyroidism Myopathy Uncontrolled diabetes Severe hypertension

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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52 participants in 3 patient groups

pravastatin

Active Comparator group

Treatment:

Drug: pravastatin, valsartan, pravastatin+valsartan

valsartan

Active Comparator group

Treatment:

Drug: pravastatin, valsartan, pravastatin+valsartan

pravastatin combined with valsartan

Active Comparator group

Treatment:

Drug: pravastatin, valsartan, pravastatin+valsartan