Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial)

Yong Seog Oh

Status and phase: Completed; Phase 3

Conditions: Atrial Fibrillation; Persistent Common Pulmonary Vein

Treatments: Drug: Adenosine arm

Study type: Interventional

Funder types: Other

Identifiers

NCT01932112

APPLE

Details and patient eligibility

About

The investigators studied the effects of adenosine on the reconnection rate after successful pulmonary veins isolation by radiofrequency catheter ablation in patients with drug-resistant atrial fibrillation

Full description

Pulmonary vein isolation has emerged as an effective therapy for paroxysmal atrial fibrillation. However, atrial fibrillation recurs in up to 50% of patients, generally because of recovery of pulmonary vein conduction.

Adenosine given during the initial procedure may reveal dormant pulmonary vein conduction, thereby identifying the need for additional ablation, leading to improved outcomes.

Enrollment: 378 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed atrial fibrillation
• recurrence of symptomatic atrial fibrillation in spite of Antiarrhythmic drug use
• written informed consent

Exclusion criteria

• intracardiac thrombus
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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378 participants in 1 patient group

adenosine arm

Other group

Description:

single arm study

Treatment:

Drug: Adenosine arm