Adenosine vs Diltiazem for Treatment of SVT in the ED (COMFORT-ED)

Anne E. Zepeski

Status and phase: Enrolling; Phase 4

Conditions: Supraventricular Tachycardia (SVT)

Treatments: Drug: diltiazem; Drug: adenosine

Study type: Interventional

Funder types: Other

Identifiers

NCT06993038

202412202

Details and patient eligibility

About

This is a small, pilot study with a primary goal of assessing patient perceptions of two medication treatments for supraventricular tachycardia in adult patients treated in the Emergency Department.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adult patients (18 years and older)
2. Diagnosis of acute, stable SVT in the emergency department

Exclusion criteria

1. Receipt of IV AV-nodal blocking agents prior to study enrollment (includes adenosine, non-dihydropyridine calcium channel blockers, beta-antagonists in pre-hospital and/or hospital setting).
2. Reported or confirmed personal history of Wolff-Parkinson-White (WPW) syndrome
3. History of heart failure with reduce ejection fraction (HFrEF) (LVEF</= 40%)
4. Severe bronchoconstrictive lung disease
5. Prior hypersensitivity to study medication
6. Previously enrolled in pilot study
7. Pregnant
8. Incarcerated

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Adenosine

Active Comparator group

Treatment:

Drug: adenosine

Diltiazem

Active Comparator group

Treatment:

Drug: diltiazem