Adequate Definition of Delayed Graft Function in Living and Deceased Donor Kidney Transplantation

Samsung Medical Center

Status: Completed

Conditions: Deceased Donor Kidney Transplantation; Living Donor Kidney Transplantation

Treatments: Procedure: kidney transplantation, living or deceased donor

Study type: Observational

Funder types: Other

Identifiers

NCT02080117

2013-12-089

Details and patient eligibility

About

It is required to establish an adequate definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function and find the definition that can predict graft function survival best in deceased donor kidney transplantation.

Full description

Delayed graft function after kidney transplantation has been reported to be an important predictor for poor short and long-term survival. Delayed graft function increases post-transplantation morbidity, hospital stay, and incidence of premature graft failure. However, the definition of delayed graft function varies and more than ten definitions have been used in previous studies. Although the definition using dialysis requirements during seven days after transplantation has been used most frequently, dialysis may be required without any evidence of renal damage during one week after transplantation. Furthermore, the incidence of delayed graft function in living donor kidney transplantation using this definition has been reported to be relatively low (as low as 1.6%) compared with the incidence in deceased donor kidney transplantation (up to 50%). Therefore, it is required to establish a better definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function in deceased donor kidney transplantation and find the definition that can predict graft function survival best in deceased donor kidney transplantation.

Enrollment: 800 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who underwent living or deceased donor kidney transplantation between 2008 and 2013

Exclusion criteria

• incomplete data of postoperative creatinine during ten days after transplantation or postoperative urine output during three days after transplantation
• patients who underwent retransplantation
• patients who expired for reasons other than kidney transplantation

Trial design

800 participants in 1 patient group

patients who underwent kidney transplantation

Description:

patients who underwent living or deceased donor kidney transplantation between 2008 and 2013

Treatment:

Procedure: kidney transplantation, living or deceased donor