ADHD: Gaps Between Patients With Alcohol-dependence and Impact on Relapse (AGADIR)

University Hospital, Lille

Status: Completed

Conditions: Alcoholism; Attention Deficit Disorder With Hyperactivity

Treatments: Behavioral: cognitive and psychiatric assessment

Study type: Observational

Funder types: Other

Identifiers

NCT02364817

2014-A00132-45 (Other Identifier)

2013_09

Details and patient eligibility

About

Some recent studies have found that adult attention deficit - hyperactivity disorder (ADHD) was frequent among patients with alcohol-dependence. However, no investigation has ever addressed whether ADHD may impact the drinking outcome.

Moreover, most of the different aforementioned studies assessed ADHD using the ADHD self-report scale (ASRS). The ASRS is a screening questionnaire that is of limited diagnostic value, and the overrepresentation of high-score ASRS among patients with alcohol-dependence could be in part due to differential diagnoses such as antisocial or borderline personality disorders, executive function impairments, or isolated impulsiveness.

The study aims to evaluate "ADHD: Gaps between patients with Alcohol Dependence and Impact on early Relapse" (AGADIR). In AGADIR, subjects with alcohol-dependence are recruited at the end of a residential detoxification program. They are assessed for ADHD using the ASRS, but also with a standardized diagnostic tool, i.e., the Diagnostic Interview for ADHD in adults (DIVA 2.0). Potential differential diagnoses are screened during the baseline visit. The patients are followed-up during the 12 first post-detox weeks, through a standardized psychosocial treatment. ASRS is re-performed at the end of the follow-up.

Enrollment: 113 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• current DSM-IV-Tr criteria for alcohol-dependence
• current residential alcohol detoxification program

Non-inclusion Criteria:

• concurrent alcohol withdrawal symptoms, i.e., CIWA-Ar ≥ 10
• benzodiazepine diazepam-equivalent dose > 30 mg
• medical history of neurological impairment (excluding alcohol-induced cognitive disorders)
• guardianship or loss of liberty
• pregnant or lactating woman

Trial design

113 participants in 1 patient group

Post-Detox Cohort

Description:

All the patients included should meet Diagnostic and Statistical Manual 4th edition revised (DSM-IV-Tr) criteria for Alcohol Dependance. They are all recruited at the end of an inpatient alcohol detoxification process (see inclusion criteria). The initial screening is performed just before the end of hospitalization. The subsequent follow-up is 12 weeks-long. There is no drug for abstinence maintenance during the study. The psychosocial intervention is based on the BRENDA model.

Treatment:

Behavioral: cognitive and psychiatric assessment