Adherence, Improvement Measure (AIM) System

University of California San Francisco (UCSF)

Status and phase: Completed; Phase 3

Conditions: AIDS; Patient Compliance

Treatments: Behavioral: No SMS adherence reminder; Behavioral: SMS medication adherence

Study type: Interventional

Funder types: Other; Other U.S. Federal agency; NIH

Identifiers

NCT01252212

1RC1MH088341 (U.S. NIH Grant/Contract)

10-00019

Details and patient eligibility

About

In this project, we will work directly with underserved patients in a safety-net setting to conduct a randomized clinical trial of standard-of-care adherence counseling versus a novel adherence intervention embedded in an existing PHR that uses cellular phone short message service (SMS) reminders and patient responses to the reminders. We will compare adherence rates in both arms as assessed by antiretroviral medication concentrations in hair samples and self-report; clinical outcomes will also be compared in the two arms. The project will examine medication adherence for antiretroviral medications and treatments of common conditions such as depression, hypertension, diabetes and hypercholesterolemia.

Enrollment: 99 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Older than 18
• Evidence of HIV-1 infection, based on patient's medical history or results of laboratory tests
• Detectable Viral Load, based on patient's medical record
• Receiving primary medical care at the AIDS Program at SFGH
• Able and willing to give informed consent to be randomized to study arms
• Willing to use the patient portal
• Has a cell phone with ability to receive and send unlimited SMS texts, Patient of the HIV/AIDS Clinic at ward 86, SFGH

Exclusion criteria

Failure to meet inclusion criteria

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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99 participants in 2 patient groups

Receiving SMS alerts

Experimental group

Description:

The patients randomized to this arm will have a SMS message sent to them regarding medication adherence for antiretroviral medications, anti-hypertensive medications, anti-depressants, hyperglycemic controlling medications and hypercholesterolemia controlling medications as well as life style supportive suggestions.

Treatment:

Behavioral: SMS medication adherence

No SMS messages

Active Comparator group

Description:

The patients randomized to this arm will have a SMS message sent to them regarding healthy life style supportive suggestions.

Treatment:

Behavioral: No SMS adherence reminder