Adipokine Genetic Variations in predictingNAFLD Progression to NASH in Egyptian Patients

Cairo University (CU)

Status: Completed

Conditions: NAFLD; NASH - Nonalcoholic Steatohepatitis

Treatments: Genetic: DNA extraction

Study type: Observational

Funder types: Other

Identifiers

NCT04561895

LC ElSahel

Details and patient eligibility

About

Due to the limited data concerning Egyptian population. authors aimed to investigate the differentadipokine gene polymorphism related to non alcoholic fatty liver disease incidence, prognosis and progression to steotosis and also to find different related factors including obesitu, diabetes and liver enzymes level

Enrollment: 224 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Egyptian patients confirmed NAFLD diagnosis diabetic

Exclusion criteria

• Pregnancy and lactation, history of alcohol abuse (as defined by an average daily consumption of alcohol > 30 g/day in men and > 20 g/day women), cirrhosis, autoimmune hepatitis and other causes of liver disease (viral hepatitis, hemochromatosis, Wilson's disease), drug induced hepatitis, chronic enteropathies, Chronic kidney disease

Trial design

224 participants in 2 patient groups

control group

Description:

healthy volunteers with absence of NAFLD

Treatment:

Genetic: DNA extraction

test group

Description:

patients with confirmed NAFLD diagnosis

Treatment:

Genetic: DNA extraction