Adipokines and Ghrelin Concentrations in Different Stages of Anorexia Nervosa

Istanbul University

Status

Completed

Conditions

Anorexia Nervosa

Adipokines

Study type

Observational

Funder types

Other

Identifiers

NCT00602264

503/5052006

2005/1795

Details and patient eligibility

About

The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.

Full description

Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.

Design: The study group is composed of four groups. Group1: Treatment-naïve patients with a recent diagnosis of AN (n:19), Group 2: The weight recovered (10 % increase in body weight compared with baseline weight) subgroup of group 1 at the end of a mean 117.72±98.14 days of follow-up (n: 12), Group 3: Recovered patients with a previous history of AN but normal menstrual cycles and body weight at the present time (n:10), Group 4: Control group: constitutionally thin healthy young women with normal menstrual cycles (n:10). Venous blood was obtained for measurements of biochemical parameters, ApN, leptin and ghrelin and body composition was determined by bioimpedance analysis.

Enrollment

41 patients

Sex

Female

Ages

16 to 32 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Diagnosis of anorexia nervosa for Group 1-3
Constitutionally thin healthy subjects for Group 4

Exclusion criteria

Medical or psychiatric diagnosis other than anorexia nervosa,
History of gastrointestinal disease for Group 1-3
History of eating disorder or gastrointestinal or psychiatric disease for control group