Adipokines Effect in Myometrial Contractility

University of Minnesota (UMN)

Status: Completed

Conditions: Myometrium; Contractility; GDM; Obesity

Treatments: Biological: Adiponectin and TNFa

Study type: Observational

Funder types: Other

Identifiers

NCT03505541

STUDY00002972

Details and patient eligibility

About

Investigate the effect of two adipokines which are adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery

Enrollment: 60 patients

Sex: Female

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant patients scheduled for a CS at 37-41 weeks of gestation at M Health Birth Place
• Participants age ≥18.
• Full informed consent able to be provided by the participant.

Exclusion criteria

• Patients undergoing general anesthesia for their CS.
• Pre-gestational DM, and DM diagnosed <24 weeks gestation.
• Patients unable to consent for themselves
• Multiple gestation

Trial design

60 participants in 3 patient groups

Control group

Description:

Healthy, term, non-obese (BMI \< 30) pregnant women with a singleton gestation scheduled for CS delivery at 37-41 weeks of gestation.

Treatment:

Biological: Adiponectin and TNFa

Study group 1

Description:

Term pregnant, non-obese (BMI \<30), diagnosed with gestational diabetes, scheduled for CS delivery between 37-41 weeks of gestation.

Treatment:

Biological: Adiponectin and TNFa

Study group 2

Description:

Term pregnant, obese (BMI \>30), non-diabetic and scheduled for CS delivery between 37-41 weeks of gestation

Treatment:

Biological: Adiponectin and TNFa