Adipokines of Epicardial Adipose Tissue and Atherosclerosis of Coronary Arteries

University Hospital, Ioannina

Status: Unknown

Conditions: Coronary Atherosclerosis; Adipokines

Study type: Observational

Funder types: Other

Identifiers

NCT03322332

741

Details and patient eligibility

About

The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.

Full description

The aim of the study is to investigate whether the expression and production of four adipokines [adiponectin, omenin-1, resistin and retinol binding protein-4 (RBP4)] secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis. Specifically, this study aims to investigate whether the expression and production of these adipokines is different between two sites of the heart, that are perfused by coronary arteries with different degrees of stenosis.

Enrollment: 160 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Individuals undergoing cardiac surgery

Exclusion criteria

• Age < 18 years
• HbA1c > 7.0%
• Any change of antidiabetic medication the previous 3 months before the surgery
• GFR < 60 mL/min/1.73 m2
• Liver disease
• Cancer
• Non-treated hyperthyroidism or hypothyroidism
• Autoimmune disease
• Infection
• Any change in body weight at least 5% the previous 3 months before surgery
• Significant dehydration.
• Taking any of the following drugs the previous 3 months before surgery: hormones, antiobesity drugs

Trial design

160 participants in 8 patient groups

NonDM-0

Description:

Nondiabetics without significant stenoses (\> 50%) in the coronary arteries

NonDM-L

Description:

Nondiabetics with significant stenosis in the left anterior descending (LAD) coronary artery or in the Left main (LM) coronary artery, but without significant stenosis in the right coronary artery (RCA)

NonDM-R

Description:

Nondiabetics without significant stenosis in the LAD and in the LM, but with significant stenosis in the RCA

NonDM-LR

Description:

Nondiabetics with significant stenosis in the LAD or in the LM and with significant stenosis in the RCA

DM-0

Description:

Patients with type 2 diabetes mellitus (T2DM) without significant stenoses in the coronary arteries

DM-L

Description:

T2DM patients with significant stenosis in the LAD or in the LM, but without significant stenosis in RCA

DM-R

Description:

T2DM patients without significant stenosis in the LAD and in the LM, but with significant stenosis in the RCA

DM-LR

Description:

T2DM patients with significant stenosis in the LAD or in the LM and with significant stenosis in the RCA