Adiponectin and Circulating Progenitor Cells (CPC) Function

University of Leipzig

Status and phase: Completed; Phase 1

Conditions: Coronary Artery Disease

Treatments: Other: exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT01272674

adipo2008

Details and patient eligibility

About

Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ≤ 75 years of age
• stable coronary artery disease
• preserved left ventricular function
• physical work capacity of ≥ 50
• successful elective percutaneous coronary intervention at study begin

Exclusion criteria

• diabetes mellitus
• hypercholesterolemia
• untreated hypertension
• smoking
• myocardial infarction within the last 4 weeks
• significant stenosis of the left main coronary artery

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 3 patient groups

exercise training

Active Comparator group

Description:

4 weeks of supervised physical exercise training

Treatment:

Other: exercise training

control

No Intervention group

Description:

sedentary lifestyle

healthy control

No Intervention group