Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome? (ChildObes)

Alexandru Florin Rogobete

Status: Completed

Conditions: Obesity, Metabolically Benign

Treatments: Other: MetS-; Other: MetS+

Study type: Observational

Funder types: Other

Identifiers

NCT03354676

12870

Details and patient eligibility

About

Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

Full description

The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the "Louis Turcanu" Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.

Enrollment: 122 patients

Sex: All

Ages: 4 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• obese children (BMI> 95th percentile)

Exclusion criteria

• obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Trial design

122 participants in 2 patient groups

MetS+

Description:

Obese group with metabolic syndrome/Data processing from Patient Medical Files

Treatment:

Other: MetS+

MetS-

Description:

Obese group without metabolic syndrome/Data processing from Patient Medical Files

Treatment:

Other: MetS-