Adjunct Photodynamic Therapy in Chronic Periodontitis Among Cigarette-smokers.

King Saud University

Status: Completed

Conditions: Chronic Periodontitis; Smoking

Treatments: Device: Photodynamic therapy; Procedure: Scaling and root planing (SRP)

Study type: Interventional

Funder types: Other

Identifiers

NCT03308019

FR-17-87

Details and patient eligibility

About

This study evaluates the efficacy of scaling and root planing with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of chronic periodontitis (CP) among cigarette-smokers and never-smokers.

Full description

The following inclusion criteria were entailed: (a) Self-reported habitual cigarette-smokers; (b) self-reported never-smokers; (c) patients with CP (presence of at least 30% sites with ≥ 3 mm of CAL and PD ≥ 3 mm 18, 19 ). The exclusion criteria were as follows: (a) patients with systemic diseases such as acquired immune deficiency syndrome/HIV and diabetes mellitus; (b) habitual smokeless tobacco product and alcohol users; (c) third molars and fractured teeth with embedded root remnants and edentulous individuals; (d) patients with misaligned teeth; and (e) patients that reported to have used antibiotics, non-steroidal anti-inflammatory drugs and/or steroids within the past 90 days.

Demographic information was collected using a questionnaire. Cigarette-smokers (group-1) and never-smokers (group-2) with chronic periodontitis were included. Treatment wise, these individuals were divided into two subgroups as follows: (a) SRP alone and (b) SRP with adjunct aPDT. Periodontal parameters (plaque index [PI], bleeding on probing [BOP], clinical attachment loss [CAL] and probing pocket depth ≥4mm [PD] were measured at baseline and at 1 month and 3 months' follow-up.

Enrollment: 83 patients

Sex: Male

Ages: 42 to 52 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Self-reported habitual cigarette-smokers.
• Self-reported never-smokers.
• Patients with chronic periodontitis (presence of at least 30% sites with ≥ 3 mm of CAL and PD ≥ 3 mm.

Exclusion criteria

• Patients with systemic diseases such as acquired immune deficiency syndrome/HIV and diabetes mellitus.
• Habitual smokeless tobacco product and alcohol users.
• Third molars and fractured teeth with embedded root remnants and edentulous individuals.
• Patients with misaligned teeth.
• Patients that reported to have used antibiotics, non-steroidal anti-inflammatory drugs and/or steroids within the past 90 days.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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83 participants in 2 patient groups

Adjunctive photodynamic therapy

Experimental group

Description:

This arm will be given scaling and root planing (SRP) with adjunctive photodynamic therapy (aPDT)

Treatment:

Device: Photodynamic therapy

Procedure: Scaling and root planing (SRP)

Dental scaling

Active Comparator group

Description:

This arm will be given scaling and root planing (SRP) only

Treatment:

Device: Photodynamic therapy

Procedure: Scaling and root planing (SRP)