Adjunct Use of Diode Laser Therapy and Omega 3 Gel in Local Drug Delivery Approach on The Treatment of Localized Aggressive Periodontitis

Tanta University

Status: Completed

Conditions: Localized Aggressive Periodontitis; Diode Laser Therapy; Omega 3

Treatments: Procedure: Scaling-root planning (SRP)+ omega 3 gel; Procedure: Scaling-root planning (SRP)+ laser therapy+ omega 3 gel; Procedure: Scaling-root planning (SRP); Procedure: Scaling-root planning (SRP)+ laser therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT07056257

R-OMPDR-4-22-11

Details and patient eligibility

About

This study aims to evaluate and compare the effect of combination therapy between diode laser and omega3 gel in the local drug delivery approach as an adjunct to scaling and root planning on the management of localized aggressive periodontitis clinically and immunologically.

Full description

Periodontitis is a disease of the periodontium occurring in an otherwise healthy adolescent, which is characterized by a rapid loss of alveolar bone about more than one tooth of the permanent dentition.

The laser approach is an efficient and atraumatic technique to enhance its use for periodontal treatment. Within the limits of scientific data, treatment with diode laser and SRP showed a higher effect than SRP or laser alone.

Omega3 Polyunsaturated fatty acids (PUFA) have well recognized anti-inflammatory properties. They decrease inflammation through multiple pathways.

Enrollment: 52 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed with localized aggressive periodontitis.
• Patients must be medically free.
• Optimal compliance as evidenced by no missed treatment appointments and a positive attitude to maintain oral hygiene.
• Patients who are willing to participate in this study can enroll and complete it.

Exclusion criteria

• Patients with generalized aggressive periodontitis. Patients are over 35 years old.
• Pregnancy.
• Patients had scaling and root planning or antibiotic therapy in the last 6 months.
• Patients with hypersensitivity to fish oil.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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52 participants in 4 patient groups

Group I

Active Comparator group

Description:

Thirteen sites \[scaling-root planning (SRP)\] were used as a control group.

Treatment:

Procedure: Scaling-root planning (SRP)

Group II

Experimental group

Description:

Thirteen sites \[scaling-root planning (SRP)+ laser therapy with application of methyl cellulose gel at repeated times weekly for one month\].

Treatment:

Procedure: Scaling-root planning (SRP)+ laser therapy

Group III

Experimental group

Description:

Thirteen sites \[scaling-root planning (SRP) + omega 3 gel repeated time weekly for one month\].

Treatment:

Procedure: Scaling-root planning (SRP)+ omega 3 gel

Group IV

Experimental group

Description:

Thirteen sites \[combination therapy between scaling-root planning (SRP) + laser + omega 3 gel in repeated time weekly for one month\].

Treatment:

Procedure: Scaling-root planning (SRP)+ laser therapy+ omega 3 gel