Adjunctive Effect of Photodynamic Therapy on Halitosis

Federal University of Minas Gerais

Status: Completed

Conditions: Periodontitis; Halitosis

Treatments: Radiation: Full-mouth scaling combined with antimicrobial photodynamic therapy; Procedure: full-mouth scaling

Study type: Interventional

Funder types: Other

Identifiers

NCT06764342

30378613.5.0000.5149

NTC02368678 (Registry Identifier)

Details and patient eligibility

About

The present study aims to evaluate bad breath in patients undergoing gingival treatment combined with tongue scraping and laser and to assess its potential benefits for both periodontal and microbiological condition. Firs patients will be selected among those who participated in a privies study. Additional patients will be also invited. They must have gum disease and bad breath. Treatments will be completed within 24 hours and oral samples will be collected with thin paper points. Bad breath will be evaluated by a professional and a specific gas machine.

Full description

The present study aims to evaluate halitosis in patients undergoing non-surgical periodontal therapy [(Full-mouth disinfection (FMD) combined with tongue scraping and antimicrobial photodynamic therapy (aPDT), and to assess its potential benefits for both periodontal and microbiological condition. A pilot study will be performed with participants who took part almost 10 years ago in the study NCT02368678. They will be invited by phone contact. In addition, new participants will be recruited by convenience in dental clinics from the Federal University of Minas Gerais until completion of 20 participants per group. Individuals with stage III periodontitis and halitosis (organoleptic method > 2), will be allocated into two periodontal treatment groups. Halitosis will be assessed using the organoleptic method and gas chromatography (OralChroma device) at three time points: before and after treatments. Microbiological samples will be collected before and after treatments from periodontal pockets and pooled samples from the tongue dorsum. These samples will be analyzed by using real-time PCR (q-PCR) aiming at detecting target bacterial species.

Enrollment: 40 patients

Sex: All

Ages: 30 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• self-reported halitosis;
• organoleptic score >2;
• stage III periodontitis;
• at least 14 teeth.

Exclusion criteria

• smokers or former smokers;
• individuals diagnosed with diabetes and/or immune diseases;
• pregnant or lactating women;
• individuals with removable partial dentures and/or fixed or removable orthodontic appliances;
• systemic use of antibiotics or anti-inflammatory drugs in the last three months; - individuals who required prophylactic antibiotics for periodontal exams and treatments;
• individuals who regularly used or had used any type of mouthwash in the past three months;
• individuals who underwent periodontal treatment in the six months prior to the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Full-mouth scaling

Active Comparator group

Description:

Full-mouth ultrasonic and manual periodontal instrumentation

Treatment:

Procedure: full-mouth scaling

Full-mouth scaling combined with antimicrobial photodynamic therapy

Experimental group

Description:

Full-mouth ultrasonic and manual periodontal instrumentation combined with antimicrobial photodynamic therapy applied to tongue dorsum and periodontal pockets

Treatment:

Radiation: Full-mouth scaling combined with antimicrobial photodynamic therapy