Adjunctive Methods In Treatment Of Odontogenic Keratocyst

Tanta University

Status: Completed

Conditions: Keratocysts of the Jaw

Treatments: Procedure: cyst enucleation; Procedure: Enucleation

Study type: Interventional

Funder types: Other

Identifiers

NCT06820229

Research Ethics CommiOS07-22/2

Details and patient eligibility

About

The purpose of this study was to compare both clinically and radiographically the effect of using 5- fluorouracil cream (5-FU) versus modified carnoy's solution (MCS) as adjunctive methods in treatment of odontogenic keratocyst (OKC).

Patients and methods :This is an interventional, comparative study that was carried on 20 patients with mandibular odontogenic keratocyst and were divided randomly into two equal groups, Group I: included 10 patients in whom OKCs were treated with enucleation and peripheral ostectomy followed by application of 5-FU cream. Group II: included 10 patients in whom OKCs were treated with enucleation and peripheral ostectomy followed by application of MCS. All patients were followed up for 9 months postoperatively.

Enrollment: 20 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with biopsy proved odontogenic keratocyst

Exclusion criteria

• relevant systemic diseases which might affect healing process.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

5-FU cream Group

Active Comparator group

Description:

The entire cyst lining was radically enucleated, followed by thorough curettage of the cavity After enucleation and peripheral ostectomy a sterile radiopaque gauze coated with 5-fluorouracil cream 5% and put into the surgical cavity.

Treatment:

Procedure: Enucleation

Procedure: cyst enucleation

Modified carnoy's solution Group

Active Comparator group

Description:

The entire cyst lining was radically enucleated, followed by thorough curettage of the cavity A gauze was soaked in modified carnoy's solution and applied to the surgical cavity for 3 minutes Following the enucleation and peripheral ostectomy of the cyst.

Treatment:

Procedure: Enucleation

Procedure: cyst enucleation