Adjunctive Photodynamic Therapy in the Treatment of Chronic Periodontitis

Tehran University of Medical Sciences

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Chronic Periodontitis

Treatments: Other: Adjunctive Photodynamic Therapy; Other: applying Photosensitizer; Other: Light-emitting diod Irradiation

Study type: Interventional

Funder types: Other

Identifiers

NCT01330082

09123209916

Details and patient eligibility

About

The aim of this randomized clinical trial is to clinically evaluate the effectiveness of the adjunctive use of photodynamic therapy (PDT) with an light-emitting diode (LED) light source in the treatment of chronic periodontitis.

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. clinically diagnosis of advanced chronic periodontitis with more than 3 mm clinical attachment loss
2. presence of at least two teeth with probing depth of 4 to 6 mm without furcation involvement in each quadrant
3. at least 16 remaining teeth
4. no periodontal treatment in the past 12 months
5. no evidence of systemic disease related to periodontal problems
6. no use of antibiotics for the past 6 months
7. No smoking more than 10 cigarettes per day
8. no addiction to any kind of drugs
9. no pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Quadruple Blind

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16 participants in 3 patient groups

Photodynamic therapy

Experimental group

Description:

will be treated by PDT using Light-emitting diod(LED) (625-635nm,200mw/cm2 ,30 s for each site, fotoson CMS Dental ,Denmark) in the presence of toluidine blue O (TBO)

Treatment:

Other: Adjunctive Photodynamic Therapy

Light-emitting diode Irradiation

Experimental group

Description:

will be treated only by using Light-emitting diode(LED) (625-635nm,200mw/cm2 ,30 s for each site, fotoson CMS Dental ,Denmark)

Treatment:

Other: Light-emitting diod Irradiation

applying photosensitizer

Experimental group

Description:

will be treated only by toluidine blue O

Treatment:

Other: applying Photosensitizer