Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis

Facultad Nacional de Salud Publica

Status and phase: Completed; Phase 4

Conditions: Aggressive Periodontitis

Treatments: Other: scaling and systemic moxifloxacin; Other: scaling and root planing

Study type: Interventional

Funder types: Other

Identifiers

NCT02125812

002

Details and patient eligibility

About

The adjunctive use of systemically administered antibiotics has been shown to provide a better clinical outcome, particularly in terms of probing depth (PD) reduction and attachment-level gain than SRP in subjects with Aggressive Periodontitis.

The overall objective of this study is to evaluate the clinical and microbiological efficacy of moxifloxacin as an adjunct to scaling and root planing versus scaling and root planing over placebo in the treatment of aggressive periodontitis.

Enrollment: 40 patients

Sex: All

Ages: 15 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• under 30 years old and systemically healthy, with at least 20 teeth present. Be willing to participate in the study which is corroborated by signing the informed consent form.

Commit to attend post-therapeutic controls and stop drinking alcohol during the time of ingestion of antibiotics.

Exclusion criteria

• Subjects in whom are contraindicated or with hypersensitivity to quinolones - Subjects who have undergone periodontal, surgical or mechanical antibiotic therapy six months before the start of the study according to interrogation.

Women in pregnancy or lactation, corroborated with previous medical history and medical consultation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 2 patient groups, including a placebo group

scaling and root planing

Placebo Comparator group

Description:

scaling and root planing

Treatment:

Other: scaling and root planing

scaling and systemic moxifloxacin

Experimental group

Description:

scaling and root planing combined with systemic moxifloxacin

Treatment:

Other: scaling and systemic moxifloxacin