Adjunctive Usage of a Moisturizing Lotion (Cetaphil® Moisturizing Lotion) to Limit the Skin Irritation Linked to the Set-Up of a Treatment by Topical Retinoid (Differin® Gel 0,1%) in Healthy Subjects of Chinese Origins

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Galderma

Status and phase

Completed
Phase 4

Conditions

Healthy Skin

Treatments

Other: Cetaphil®
Drug: adapalen 0.1%

Study type

Interventional

Funder types

Industry

Identifiers

NCT00971282
RD.03.SPR.29076

Details and patient eligibility

About

This is a single-center study, randomized, Investigator/Evaluator-blinded bilateral (split-face) comparison. The objective: To assess the benefit of the concomitant use of a Moisturizing Lotion in reducing the skin irritation induced by a adapalen gel treatment in Chinese Subjects.

Full description

The interest & relevance of the concomitant use of a non-comedogenic moisturizer in order to decrease retinoid irritation has already been demonstrated in Caucasian patients. Such interest of associating a moisturizer when Differin® gel is prescribed has not been demonstrated in Asian populations.

Enrollment

30 patients

Sex

All

Ages

21+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • male or female subjects of Chinese origins
  • aged 21 years or older
  • with healthy skin;

Exclusion criteria

  • skin pigmentation which interferes with the reading of skin reactions
  • with sunburn, eczema, atopic dermatitis, perioral dermatitis, or rosacea on the area to be treated
  • with a washout period for the following topical treatment(s) Corticosteroids, oher anti-inflammatory drugs, retinoids
  • with a washout period for the following systemic treatment(s): Medications that may increase photosensitivity, corticosteroids, anti-inflammatories, retinoids

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

Single Blind

30 participants in 1 patient group

intra-individual comparison
Experimental group
Treatment:
Drug: adapalen 0.1%
Other: Cetaphil®

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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