Adjunctive Use Of A Novel Hyaluronic Acid/Chlorhexidine Gel In The Non Surgical Treatment Of Periodontitis

University of Sharjah

Status: Enrolling

Conditions: Periodontitis; Chlorhexidine; Hyaluronic Acid

Treatments: Procedure: Non surgical periodontal therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05682833

REC-22-02-26-S

Details and patient eligibility

About

General Objective :

To evaluate the outcome of non surgical periodontal therapy with local drug delivery adjunct to scaling and root planning

Specific Objective :

To determine the effect of intra-pocket application of hyaluronic acid /chlorohexidine gel in non surgical periodontal treatment on clinical periodontal parameters and microbiological level .

Enrollment: 20 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age : 20-60 years old
• At least 20 remaining teeth
• Periodontitis stage III and IV ,Grade A, B and C

Exclusion criteria

• Patients taking specific medications: antibiotic , anticoagulants or anti-inflammatory
• Previous periodontal therapy in the past 3-6 months.
• Immunocompromised patients
• Systemically diseased patients: Diabetes ,osteoporosis etc
• History of allergies or hypersensitivity reactions to chlorohexidine or Hyaluronic acid
• Pregnant or lactating women.
• Heavy Smokers (more than 20/day)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

20 participants in 2 patient groups, including a placebo group

Test

Experimental group

Description:

NS therapy + Chlorhexidine/Hyaluronic acid subgingival gel application

Treatment:

Procedure: Non surgical periodontal therapy

Control

Placebo Comparator group

Description:

NS therapy + Placebo gel subgingival application

Treatment:

Procedure: Non surgical periodontal therapy