Adjuvant Chemoradiation Following Radical Resection of Pancreatic Ductal Adenocarcinoma, a Prospective Cohort Study

Fudan University

Status: Unknown

Conditions: Resectable Pancreatic Cancer; Surgery; Adjuvant Chemoradiotherapy

Treatments: Radiation: Adjuvant chemoradiotherapy + Adjuvant chemotherapy; Other: Follow-up only; Radiation: Adjuvant chemoradiotherapy; Drug: Adjuvant chemotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT04737551

A-RPC

Details and patient eligibility

About

This is a prospective observation cohort study to evaluate efficacy of different types of adjuvant therapy strategies, including chemoradiotherapy, chemotherapy alone, or no adjuvant treatment, for pancreatic ductal adenocarcinoma patients who received surgical resection of primary cancer.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age between 18 to 90 years.
2. Received surgical resection of primary tumor.
3. Histological diagnosis of pancreatic ductal adenocarcinoma.
4. Signed informed consent.

Exclusion criteria

1.Active concomitant malignancy (Malignancy other than pancreatic cancer).

Trial design

400 participants in 4 patient groups

No adjuvant treatment

Description:

Pancreatic cancer patients who received surgery without subsequent adjuvant treatment.

Treatment:

Other: Follow-up only

Adjuvant chemotherapy

Description:

Pancreatic cancer patients who received surgery and only adjuvant chemotherapy.

Treatment:

Drug: Adjuvant chemotherapy

Adjuvant chemoradiotherapy

Description:

Pancreatic cancer patients who received surgery and only adjuvant chemoradiotherapy.

Treatment:

Radiation: Adjuvant chemoradiotherapy

Adjuvant chemoradiotherapy + adjuvant chemotherapy

Description:

Pancreatic cancer patients who received surgery and both adjuvant chemoradiotherapy and chemotherapy.

Treatment:

Radiation: Adjuvant chemoradiotherapy + Adjuvant chemotherapy