Adjuvant Hypofractionation Radiotherapy for Thymic Epithelial Tumours After Complete Resection

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Enrolling

Conditions: Thymus Neoplasms

Treatments: Radiation: Adjuvant Hypofractionation Radiotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT06189183

NCC4287

Details and patient eligibility

About

The purpose of this study is to evaluate the efficiency and toxicity of adjuvant hypofractionation radiotherapy for thymic epithelial tumours after complete resection.

Full description

Adjuvant Radiotherapy(Postoperative radiotherapy) is proposed in stage II and III thymic carcinoma，stage III thymoma，stage IIB B2/B3 thymomas.

Hypofractionation Radiotherapy is used in this study. The purpose of this study is to evaluate the efficiency and toxicity of adjuvant hypofractionation radiotherapy for thymic epithelial tumours after complete resection.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Thymoma and Thymic carcinoma confirmed by histology or cytology
• R0 resection (complete resection)
• stage II and III thymic carcinoma，stage III thymoma，stage IIB B2/B3 thymomas.
• Karnofsky performance status(KPS) 80, 90 or 100.
• Having sufficient Pulmonary function, renal function and liver function. Neutrophile granulocyte count>1.5×109 /L, platelet count>80×109 /L, hemoglobin ≥10g/dL.

Exclusion criteria

• Prior thoracic radiotherapy.
• Uncontrolled Comorbidities.
• Pregnant or nursing mother.
• Pneumonia

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Adjuvant Hypofractionation Radiotherapy

Experimental group

Description:

Adjuvant Hypofractionation Radiotherapy for Thymic Epithelial Tumours After Complete Resection

Treatment:

Radiation: Adjuvant Hypofractionation Radiotherapy