ADMA and Mechanical Ventilation in Preterm Infants

Amsterdam UMC, location VUmc

Status: Completed

Conditions: Premature Birth

Study type: Observational

Funder types: Other

Identifiers

NCT00460044

HK0607

Details and patient eligibility

About

The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.

Full description

Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.

Sex: All

Ages: Under 32 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Gestational age < 32 weeks
• Birth weight < 1500 gram
• Written informed consent of parents

Exclusion criteria

• Congenital abnormalities
• Chromosomal abnormalities