Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia

University of Chile

Status and phase: Completed; Phase 4

Conditions: Hyperalgesia; Opioid-Related Disorders

Treatments: Drug: Placebo Oral Tablet; Drug: Acetazolamide

Study type: Interventional

Funder types: Other

Identifiers

NCT02992938

803/16

Details and patient eligibility

About

Remifentanil is a potent opioid widely used during the administration of general anesthesia. There is a lot of evidence that suggest that the used of remifentanil is associated with the development of hyperalgesia (a reduction of nociceptive thresholds). However, the mechanism of this hyperalgesia is not fully understood.

Recently, it was demonstrated that the disruption of the Cl- homeostasis could be involved. Interestingly, this was prevented in a murine model with the administration of Acetazolamide, a carbonic anhydrase inhibitor. In our clinical trial we will try to determine if the preoperative administration of acetazolamide could prevent the hyperalgesia induced by remifentanil in patients scheduled for thyroidectomy with general anesthesia.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for thyroidectomy with general anesthesia in the University of Chile Clinical Hospital

Exclusion criteria

• Patients ASA III y IV
• Chronic pain history
• Drug and alcohol abuse
• Chronic use of opioid and sedatives
• Neuropsychiatric illness
• NSAID and other analgesics used the 48 hours previous to the surgery
• CMI > 30

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups, including a placebo group

Acetazolamide

Experimental group

Description:

250 mg VO of acetazolamide will be administered the day of the surgery 2 hours before anesthesia induction

Treatment:

Drug: Acetazolamide

Placebo

Placebo Comparator group

Description:

An oral tablet without active principle acetazolamide but with the same physical characteristics will be administered the day of the surgery 2 hours before anesthesia induction

Treatment:

Drug: Placebo Oral Tablet