Administration of Human Chorionic Gonadotrophin Before Secretory Transformation of Frozen-thawed Embryo Transfer Cycles

Alexandria University

Status and phase: Completed; Phase 4

Conditions: Frozen-thawed Embryo Transfe; hCG; Human Chorionic Gonadotrophin; FET

Treatments: Drug: Human Chorionic Gonadotrophin Intramuscular injection 10.000 IU

Study type: Interventional

Funder types: Other

Identifiers

NCT05340010

HCG in FET cycles

Details and patient eligibility

About

Successful embryo implantation is complicated process that requires synchrony between good-quality embryos and receptive endometrium. Human chorionic gonadotropin (hCG), is one of the initial embryonic signals and the major embryoendometrial relationship regulator. This study will be conducted to to investigate the role of parenteral hCG used for the transfer of cryopreserved- thawed embryos with HRT cycles in the outcome of artificially prepared frozen embryo transfer (FET) cycles.

Enrollment: 180 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patient age ≤ 38 years.
• Normal 3D transvaginal ultrasound.
• At least two good quality embryos cryopreserved by vitrification.
• No GnRH agonists administration before FET cycle.

Exclusion Criteria

• Endometriosis.
• Uterine anomalies.
• Evidence of hydrosalpinx by hystrosalpingography or ultrasound.
• Evidence of immune disease, hematological or hormonal disorder.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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180 participants in 2 patient groups

HCG group

Experimental group

Description:

n Group 1 (hCG): participants will receive endometrial preparation with estrogen and an intramuscular hCG injection will before progesterone supplementation

Treatment:

Drug: Human Chorionic Gonadotrophin Intramuscular injection 10.000 IU

control group

No Intervention group

Description:

Group 2 (control): participants will receive the conventional endometrial preparation with estrogen followed by progesterone supplementation