Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes (AMERICO)

The University of Alabama at Birmingham

Status: Completed

Conditions: Healthy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00726778

F040109007

R01DK067426 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in aspects of insulin secretion and action. The genetic component will be modeled by estimating the degree of European genetic admixture (ADM) obtained from approximately 50 ancestry informative markers (AIMs). The environmental components will be modeled by measuring energy intake (food intake), energy expenditure (physical activity) and socioeconomic status.

Enrollment: 360 estimated patients

Sex: All

Ages: 7 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• African American, European American, or Hispanic American, aged 7-12, healthy, weight is equal to or greater than 25 Kg

Exclusion criteria

• Type 1 or 2 diabetes, polycystic ovary disease, disturbances in glucose or lipid metabolism disturbances
• Use of medication known to affect body composition or physical activity, diagnosis of genetic disorders known to affect body composition or fat distribution
• Use of tobacco, alcohol consumption in excess of 400 g per week
• Menstruated for more than a year prior to the recruitment; OR
• A medical history that counter-indicates inclusion of the study

Trial design

360 participants in 1 patient group

A, Observational

Description:

Healthy European American, African American, and Hispanic American children aged 7-12