Adolescent Impact: A Behavioral Intervention for Adolescents Living With HIV/AIDS

Centers for Disease Control and Prevention (CDC)

Status: Completed

Conditions: HIV Infections

Treatments: Behavioral: Adolescent Impact

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00164385

U64CCU219448

U64CCU319455

U64CCU319459

CDC-NCHSTP-3723

Details and patient eligibility

About

The primary objective of Adolescent Impact is to develop and evaluate a developmentally targeted intervention designed to minimize secondary transmission risk behavior and enhance adherence to care and treatment. The intervention is delivered in 12 sessions (five one-to-one, 7 group) over a 3 month period of time. Intervention is delivered in addition to standard of care treatment at the participant's respective clinic. Participants are randomized to either an intervention or control arm; the control group receives standard of care treatment and control group participants are offered the Adolescent Impact intervention following the completion of the nine-month follow up. It is hypothesized that compared to control group participants, intervention group participants will evidence (1) improved or stable virologic and/or immunologic status, mediated by (a) adherence to prescribed antiretroviral medication and/or (b) adherence to HIV care appointments, and (2) reduction/minimization of secondary transmission risk behaviors to include (a) unprotected sex and/or needle sharing, and (b) sexual and drug use behaviors that increase risk for unprotected sex.

Full description

The primary objective of Adolescent Impact is to develop and evaluate a developmentally targeted intervention designed to minimize secondary transmission risk behavior and enhance adherence to care and treatment. The intervention is delivered in 12 sessions (five one-to-one, 7 group) over a 3 month period of time. Intervention is delivered in addition to standard of care treatment at the participant's respective clinic. Participants are randomized to either an intervention or control arm; the control group receives standard of care treatment and control group participants are offered the Adolescent Impact intervention following the completion of the nine-month follow up. It is hypothesized that compared to control group participants, intervention group participants will evidence (1) improved or stable virologic and/or immunologic status, mediated by (a) adherence to prescribed antiretroviral medication and/or (b) adherence to HIV care appointments, and (2) reduction/minimization of secondary transmission risk behaviors to include (a) unprotected sex and/or needle sharing, and (b) sexual and drug use behaviors that increase risk for unprotected sex.

Sex: All

Ages: 13 to 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Confirmed HIV infection
2. Followed at one of the participating clinics for HIV care
3. Age 13-21 at enrollment (i.e., must be enrolled prior to 22nd birthday)
4. Aware of HIV status and, for perinatally infected teens, the HIV status of one's biological mother
5. Able to comprehend English well enough to participate in the study
6. Able to understand and sign a written informed consent or assent
7. Parental or legal guardian consent, if under the age of 18 -

Exclusion criteria

1. Less than borderline intellectual functioning, as evidenced by clinician assessment or full scale IQ less than 65
2. Acute and severe mental illness (including, but not limited to, psychosis, severe depression, or significant suicidal or homicidal ideation) -

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)