Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59)

Memorial Sloan Kettering Cancer Center (MSK)

Status and phase: Completed; Phase 1

Conditions: Abnormal Hormonal Secretions; Adrenal Tumors; Electrolytes Abnormalities; Adrenal Malignancies

Treatments: Radiation: (NP-59); Procedure: Imaging, Adrenal acans

Study type: Interventional

Funder types: Other

Identifiers

NCT00591643

77-030

Details and patient eligibility

About

The purpose of this study is to find out if your adrenal glands are normal or abnormal. This can be determined by whether or not your adrenal gland concentrates more of a labeled building block of adrenal hormone, norcholesterol. This labeled material had been used as an investigative diagnostic tool for imaging adrenal glands for many years with success in our hands. This is a diagnostic procedure. CT, MRI and Ultrasound can determine the size and presence or absence of tumor but cannot assess the function of the adrenal glands. To determine hormone concentrations from blood samples would involve more invasive catherization.

Full description

To investigate the feasibility of using NP-59 to localize adrenal tumors and assess their functions under the influence of pharmacological manipulations.

Enrollment: 93 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with clinical and laboratory suspicions of hypersecretion of adrenal cortical hormones

Exclusion criteria

• n/a

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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93 participants in 1 patient group

Imaging, Adrenal acans & Radiation

Experimental group

Treatment:

Procedure: Imaging, Adrenal acans

Radiation: (NP-59)