Adrenaline V/s Dopamine in Fuid Refractory Septic Shock

Laiba Qamar

Status: Enrolling

Conditions: Fluid Refractory Septic Shock; Septic Shock

Treatments: Drug: Adrenaline; Drug: Dopamine

Study type: Interventional

Funder types: Other

Identifiers

NCT07273526

#AVDSSC24#

Details and patient eligibility

About

This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children. The efficacy will be checked based on heart rate , GCS, capillary refill time , palpable pripheral pulse , urine output and systolic blood pressure.

Full description

This is a randomized control trial in which children / patients diagnosed with Fluid refractory Septic shock will be provided with one of the two drugs ina randomzied way and their efficacy will be assesed on the basis of correction of various parameters at various points of time.

Enrollment: 90 estimated patients

Sex: All

Ages: 1 to 12 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients of both Genders having age range between 1month and 12 years with diagnosis of fluid refractory septic shock as per operational definition.

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Exclusion criteria

• Patients with

  1. cardiopumonary Bypass during last 5 days
  2. Chronic Systemic disease like Chronic kidney Disease , cerebral palsy, congenital heart disease
  3. neuromuscular discorder
  4. Metabolic disorders
  5. Those who already had treatment at periphery for hypovolemia without any record of medication or sequential organ failure at presentation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 2 patient groups

Group A

Experimental group

Description:

These patients will receive 0.1-0.3ug/kg/min of adrenaline when diagnosed with fluid refractory Septic shock .

Treatment:

Drug: Adrenaline

Group B

Active Comparator group

Description:

The patients in this arm of study will be provided with dopamine 10-20ug/kg/min when diagnosed with fluid refractory septic shock.

Treatment:

Drug: Dopamine