Adult Pulmonary Langerhans Cell Histiocytosis: a National Registry-based Prospective Cohort Study

Assistance Publique - Hôpitaux de Paris

Status: Enrolling

Conditions: Histiocytosis, Langerhans-Cell; Histiocytosis Pulmonary; Histiocytosis

Treatments: Other: Standard of care

Study type: Observational

Funder types: Other

Identifiers

NCT04665674

2014_TAZI

Details and patient eligibility

About

The long-term outcomes of adult patients with pulmonary Langerhans cell histiocytosis (PLCH), particularly survival, is largely unknown. This is the first prospective study in the field evaluating the long-term outcomes of PLCH patients. This french countrywide registry-based study included a large cohort of PLCH patients followed for a sufficiently long period to address risk factors of long-term outcomes of PLCH patients.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >= 18 years
• Diagnosis of PLCH was either histologically confirmed on a biopsy of an involved tissue, or based on the combination of the following criteria: 1) an appropriate clinical picture; 2) a typical nodulo-cystic pattern on lung high-resolution computed tomography (HRCT) and 3) exclusion of alternative diagnoses

Exclusion criteria

Trial design

500 participants in 1 patient group

Pulmonary Langerhans cell histiocytosis (PLCH)

Description:

All patients with newly diagnosed PLCH at adulthood (i.e. 18 years of age or older) referred to the French national reference centre for Histiocytoses

Treatment:

Other: Standard of care