Advanced Endoscopic Resections for Rectal Neoplasms

Jagiellonian University

Status: Not yet enrolling

Conditions: Rectal Neuroendocrine Neoplasm; Rectal Adenocarcinoma; Recurrent Rectal Adenocarcinoma; Rectal Adenoma; Rectal Cancer

Treatments: Procedure: Endoscopic submucosal dissection; Procedure: Endoscopic intramuscular dissection

Study type: Observational

Funder types: Other

Identifiers

NCT07410767

1072.6120.2.63.2026

Details and patient eligibility

About

This study evaluates how advanced endoscopic resection techniques affect treatment outcomes in adults with rectal cancer.

Rectal cancer has traditionally been treated with standard abdominal surgery. Newer endoscopic techniques allow removal of selected early tumors and may reduce treatment-related complications. However, their effectiveness and safety in tumors with deeper invasion are not yet fully established.

This multicenter retrospective observational study uses existing medical records from adults who underwent endoscopic or surgical resection of rectal tumors between 2015 and 2025. Researchers will analyze anonymized information on procedures performed and treatment outcomes to assess the safety and effectiveness of advanced endoscopic approaches.

The results of this study may help guide treatment selection and improve care for people with rectal cancer.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with rectal neoplasms treated by advanced endoscopic resection

Exclusion criteria

• hybrid resection performed
• full-thickness resection performed
• essential procedural or outcome data were unavailable

Trial design

300 participants in 2 patient groups

ESD

Description:

Patients who underwent endoscopic submucosal dissection for rectal neoplasm

Treatment:

Procedure: Endoscopic submucosal dissection

EID

Description:

Patients who underwent endoscopic intermuscular dissection for rectal neoplasm

Treatment:

Procedure: Endoscopic intramuscular dissection