Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy and Switch to an Elvitegravir-based Regimen

Mass General Brigham

Status

Completed

Conditions

HIV Disease

Treatments

Drug: Stribild (elvitegravir, cobicistat, emtricitabine and tenofovir)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01929759

NeuroHIV001

Details and patient eligibility

About

In this study we will use a multi-modal imaging approach of MRS and fMRI to comprehensively assess the biological changes in the brain associated with EFV-based regimen (EFV/FTC/TDF), specifically alterations in the brain circuitry, function and local neurochemistry, and their correlation with neuropsychological function. In a cohort of HIV-infected patients who are clinically stable on the commonly use regimen of EFV/emtricitabine (FTC)/truvada (TDF) or Atripla, we propose to replace the EFV component with a new integrase inhibitor, elvitegravir (EVG) boosted with cobicistat (COBI), given as the EVG/COBI/FTC/TDF Single Tablet Regimen (STR) to evaluate the EFV-related neural alterations. This is a multidisciplinary study which involves a team of infectious disease experts in the field of HIV, neuroradiologists with expertise in fMRI and MRS techniques to study various central nervous system and psychiatric disorders and a psychiatrist with experience and expertise in research on abnormalities of affective and motivational processing in the context of neuropsychiatric disorders. We will utilize the established clinical research platform in the Infectious Disease outpatient clinical practice at the Brigham and Women's Hospital, where there is currently have many ongoing HIV-related studies and a large panel of HIV-infected patients motivated to be involved in clinically relevant research. We propose to use advanced neuroimaging to measure biologically changes in the brain associated with long-term EFV use with the following specific aims:

Determine changes in neurometabolites measured by MRS in the brain associated with long-term EFV use
Assess for alterations in neural activity correlated with affective symptoms associated with EFV vs STR use using fMRI, and their associations with changes in neurometabolites assessed by MRS, and with changes in cognition assessed by Trail Making and Digit Substitution Tests.
Determine changes in emotion, cognition and sleep quality after switching from EFV to STR, and how they correlate with subject treatment preference.

This clinical study will extend our current understanding of EFV neurotoxicity by further defining the nature of these biological changes. Further elucidation of the neurobiological underpinnings of EFV-induced CNS toxicity will have clinical relevance in improving the quality of life and drug adherence of HIV-infected patients on ART, especially among older patients or those with baseline neuropsychiatric disorders, whom at baseline are more vulnerable to neurocognitive decline from long-term HIV infection.

Enrollment

10 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Chronic HIV-infected individuals on suppressive regimen with EFV/FTC/TDF, for at least 6 months
Undetectable HIV-1 RNA virus load for at least 6 months
No co-infections with active hepatitis B and C
Presence of at least moderate symptoms on 2 out of 3 subcores on the DASS
No known active HIV-related and non-HIV related CNS infections
Estimated glomerular filtration rate (EGFR) >60 ml/min
Consent to switching to EVG/COBI/FTC/TDF
Ages 18 - 65

Exclusion criteria

History of CNS opportunistic infections or active CNS infections
History of severe psychiatric disorder (excluding depression and anxiety)
History of chronic neurological disorders, such as epilepsy or multiple sclerosis
History of or current significant substance abuse or dependence and/or heavy alcohol use (>12 oz/wk)
Any women who may be pregnant (positive urine pregnancy test or unprotected sex in 2 weeks prior to scan) or known to be pregnant
Contraindications to undergoing fMRI, including metallic implants, claustrophobia, and medical conditions or medications that significantly affect cerebral blood flow or function.