Advanced PRF vs PRF for Gap Filling in Immediate Implants (A-PRF vs PRF)

Beni-Suef University

Status: Active, not recruiting

Conditions: Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling Material

Treatments: Procedure: Immediate Dental Implant and A-PRF; Procedure: Immediate dental implant and PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT07319494

DU:024111959

Details and patient eligibility

About

Study type: Clinical Trial

Goal:

The goal of this clinical trial is to learn if Advanced Platelet-Rich Fibrin (A-PRF) versus traditional Platelet-Rich Fibrin (PRF) can improve bone healing and soft tissue outcomes in patients undergoing immediate dental implant placement.

Main questions it aims to answer:

Does A-PRF provide greater buccal bone preservation compared to PRF after immediate implant placement?

Does A-PRF improve soft tissue healing and reduce postoperative complications compared to PRF?

Comparison group:

Researchers will compare A-PRF to PRF as a gap-filling material in immediate implants to see if A-PRF results in better bone and soft tissue outcomes.

Participants will:

Undergo tooth extraction followed by immediate implant placement

Receive either A-PRF or PRF as the gap-filling material in the implant site

Have CBCT scans at baseline and 6 months to measure bone thickness

Have clinical assessments of soft tissue healing and implant stability

Attend follow-up visits at 1 week, 1 month, 3 months, and 6 months post-surgery

Enrollment: 16 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The selected patients has a badly decayed mandibular posterior teeth which are indicated for extraction due to dental causes (periapical abscess, trauma or caries) not periodontal as diagnosed by periapical x-ray.
• Healthy patients who are classified according to the American Society of Anesthesiologists (ASA)(2022) physical status classification as class I.
• Patient age ≥ 20 years old.
• Surgical site with sufficient for implant placement.
• Sufficient interocclusal space for prosthesis.
• Good oral hygiene.
• Patients have thick biotype.
• Patients have socket class I.

Exclusion criteria

• Active periodontal diseases and periapical lesions not chronic infections.
• Patients have parafunctional
• History of alcohol or drug dependency, psychological factor that might affect the surgical or prosthodontic treatment.
• Smoking.
• Pregnant patients.
• Patients who are not willing to complete the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

PRF Group

Experimental group

Description:

Participants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with traditional Platelet-Rich Fibrin (PRF) as the gap-filling material.

Treatment:

Procedure: Immediate dental implant and PRF

A-PRF Group

Experimental group

Description:

Participants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with Advanced Platelet-Rich Fibrin (A-PRF) as the gap-filling material.

Treatment:

Procedure: Immediate Dental Implant and A-PRF