Advancing Prevention of Pulmonary Fibrosis (APPLe)

University of Colorado Denver (CU Denver)

Status: Active, not recruiting

Conditions: Pulmonary Fibrosis; IPF; ILD

Treatments: Other: Questionnaires; Diagnostic Test: Pulmonary Function Test; Radiation: High resolution CT scan of the chest; Other: Sample collection

Study type: Observational

Funder types: Other

Identifiers

NCT04564183

20-1739

Details and patient eligibility

About

This study plans to learn more about pulmonary fibrosis and how it develops. We want to determine if the disease can be detected early, before the lung is permanently scarred.

This study will enroll participants who are not currently diagnosed with pulmonary fibrosis, but who have family members with pulmonary fibrosis. Because there is an increased risk within affected families, this cohort will allow us to learn how pulmonary fibrosis develops, and how the lungs change over time.

Enrollment: 800 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Unaffected first degree relative from Familial Interstitial Pneumonia families (two or more family members with IIP)
• Age at least 40 years old and younger than 75 years old

Exclusion criteria

• Diagnosed with known (physician-diagnosed) pulmonary fibrosis prior to informed consent
• Other genetic diseases associated with interstitial lung disease
• Pregnant women

Trial design

800 participants in 1 patient group

Full Cohort

Description:

Entire study population

Treatment:

Other: Sample collection

Radiation: High resolution CT scan of the chest

Diagnostic Test: Pulmonary Function Test

Other: Questionnaires