Advantages and Disadvantages of TOXCLEAN As Add on Treatment to SOC in Patients with Clostridium Difficile-associated Diarrhea

ABResearch S.r.l.

Status: Enrolling

Conditions: Clostridium Difficile Diarrhea; Clostridium; Difficile, As Cause of Disease Classified Elsewhere

Treatments: Device: Toxclean 1g

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT06839209

TOXCCAD

Details and patient eligibility

About

This is a single center, randomized, exploratory clinical investigation that will evaluate the safety and efficacy of Toxclean (ABResearch srl) as add on treatment to Standard therapy in 24 patients with recurrent CDAD.

Eligible subjects will be adult patients with recurrent CDAD. Recurrent CDAD, for the purpose of this protocol, is defined as one or more new episode of diarrhea (Ned) within two months from the end of the SoC treatment. The objective of this pilot study is to evaluate whether 1 or 2 grams of Toxclean powder is orally administrable and well tolerated as add on treatment to SoC in patients with recurrent CDAD.

Full description

This is a single center, randomized, exploratory clinical investigation that will evaluate the safety and efficacy of Toxclean (ABResearch srl) as add on treatment to Standard therapy in 24 patients with recurrent CDAD.

Eligible subjects will be adult patients with recurrent CDAD. Recurrent CDAD, for the purpose of this protocol, is defined as one or more new episode of diarrhea (Ned) within two months from the end of the SoC treatment. The objective of this pilot study is to evaluate whether 1 or 2 grams of Toxclean powder is orally administrable and well tolerated as add on treatment to SoC in patients with recurrent CDAD. Primary

• Percentage of patients that complete Toxclean schedule treatment; Secondary
• Safety and tolerability of two different dosage of oral Toxclean treatment;
• Reduction of toxin amount in fecal sample;
• Clinical response after 28-day oral administration of two different dosage of TOXCLEAN in combination with SoC therapy;
• CDAD symptoms improvements during treatment and follow up periods;
• Fecal concentration of Toxclean;

Enrollment: 18 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years, male or female, at the time of informed consent
• Signed informed consent by patient, or where applicable, patient's legally authorized representative;
• Diagnosis of recurrent CDAD, defined as those episodes of C. Difficile associated diarrhea occurring 2-8 weeks after either the symptoms resolution of a previous CDAD episode or C. difficile negativization of fecal sample.
• Detection of C. difficile toxins by nucleic acid amplification tests (NAAT), EIA or GDH;
• Received at least one course of adequate antibiotic therapy for CDAD (≥ 10 days of vancomycin at a dose of ≥125 mg four times per day, ≥ 10 days of metronidazole at a dose of 500mg three times per day or fidaxomixin 200mg twice a day for 10 days)

Exclusion criteria

• History of C. difficile complicating inflammatory bowel disease (Crohn's disease, ulcerative colitis), or history of bowel resection surgery (other than uncomplicated appendectomy) or history of other infectious diarrhea or diarrhea of unknown etiology since the initial episode of CDAD;
• Participants who require oral anticoagulant medications, including but not limited to warfarin and NOACs (novel oral anticoagulants);
• Major gastrointestinal surgery within 3 months of enrollment;
• History of swallowing difficulties, including dysphagia or odynophagia for liquids or solids;
• Clinically immunocompromised due to any primary immune or autoimmune deficiency, as a result of chronic disease, cancer or medication used to treat these diseases
• Consumption of the following prescription medications during the current enrollment episode: Bezlotuxamab/Zinplava Is pregnant or lactating Known hypersensitivity to the active principle or excipients

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

Single dosage

Experimental group

Description:

1 g of Toxclean once a day for 28 days plus SoC therapy

Treatment:

Device: Toxclean 1g

Double dosage

Experimental group

Description:

1 g of Toxclean twice daily for 28 days plus SoC therapy

Treatment:

Device: Toxclean 1g