Adverse Health Effects of Mainstream and Secondhand Hookah Smoke in NYC Hookah Bars

NYU Langone Health

Status: Completed

Conditions: COPD

Treatments: Other: Visit a win bar; Other: Exposure to tobacco hookah second hand smoke; Other: Active smoking of Tobacco Hookah for 2 hours

Study type: Interventional

Funder types: Other

Identifiers

NCT02638194

14-00370

Details and patient eligibility

About

The primary purpose of this study is to examine the health effects of mainstream and secondhand hookah (i.e. water pipe) smoke on pulmonary and cardiovascular functions as well as serum levels of inflammatory biomarkers. Investigators would like to demonstrate that inhalation of both mainstream and secondhand smoke generated by hookah produces adverse pulmonary and cardiovascular effects and alterations in serum levels of inflammatory biomarkers.

Full description

A total of 20 participants are going to be enrolled in this study; 10 participants smoke hookah and 10 participants are exposed to second hand hookah smoke for 2 hours in NYC hookah bars. Subjects in the control group will also be paired as they were for the hookah bar visit but will visit a control location, where they will be asked to consume a similar amount of food and drink at a wine bar. Pulmonary function, cardiovascular changes, and blood and urine markers of inflammatory mediators before, immediately after and 24 hours after the participants' visits to hookah bars and wine bars will be examined. Air quality monitoring will also be performed at the hookah bar and at the control location. Physiological changes will be assessed by measuring pulmonary function, blood pressure, heart rate, and blood oxygenation status. To determine the extent of tobacco exposure and associated inflammatory changes from secondhand hookah smoke, investigators will measure blood inflammatory biomarkers, oxidative stress, gene expression, tobacco-related carcinogenic metabolites, and exhaled carbon dioxide levels.

Enrollment: 26 patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Competent adult English speaking subjects
• Have used hookah in the past

Exclusion criteria

• Age <21
• Pregnancy
• Current cigarette smokers
• Has pulmonary disease, such as asthma or Chronic Obstructive Pulmonary Disease (COPD)
• Subjects are unable to give voluntary informed consent because they are non English speaking, are unable to read or write, or any other impediments that prohibits giving written informed consent
• Recent nasal surgery (within 6 months)
• History of bleeding or other blood related disorder.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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26 participants in 2 patient groups

Hookah Smoking Group

Active Comparator group

Description:

10 participants will smoke tobacco hookah for 2 hours

Treatment:

Other: Visit a win bar

Other: Active smoking of Tobacco Hookah for 2 hours

Hookah Secondhand Smoke Group

Active Comparator group

Description:

10 individuals will be exposed to secondhand hookah tobacco smoke for 2 hours

Treatment:

Other: Exposure to tobacco hookah second hand smoke

Other: Visit a win bar