Aerobic Exercise Effects on Cognitive Function in Aging Individuals

King Saud University

Status: Completed

Conditions: Exercise Training; Cognitive Function

Treatments: Other: supervised aerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06650345

RRC-2013-015

Details and patient eligibility

About

Positive effects are exerted by participating in moderate exercise training with physical activity which positively affects body health, including cognitive abilities, among older adults. Thus, the investigators are trying to study the potential effects of the supervised aerobic training regimen for 12 weeks on cognitive function among older adults based on molecular changes in cellular apoptosis.

Full description

Physical activity exerts many positive effects on body health, including cognitive abilities, among older adults. Nevertheless, a paucity of knowledge exists regarding the potential anti-apoptotic benefits of moderate exercise and its potential influence on cognitive function. The objective of the present study was to explore the possible connection between the anti-apoptotic mechanisms associated with exercise and cognitive performance in a cohort of 60 older adults who participated in a 12-week supervised aerobic training regimen.

A total of 120 healthy home residents and older subjects with an age range of 65 to 95 years were enrolled to participate in this study. Only, 60 subjects who met the inclusion criteria were included in this study.

The participants were categorized into two groups, specifically the control group (consisting of 30 individuals) and the exercise group (also comprising 30 individuals), based on their participation in an exercise program. Assessments of cognitive function, leisure-time physical activity (LTPA), and apoptotic-related markers such as Bcl-2, p53, and Cytochrome c were conducted both before and after a 12-week aerobic exercise intervention.

Enrollment: 60 patients

Sex: All

Ages: 65 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• home resident older
• healthy individuals
• the participants were aged between 65 and 95

Exclusion criteria

• Participants with Any physical impairments or conditions such as endocrine, immune, or psychiatric disorders
• participants with eating disorders
• participants' use of any glucocorticoid medications, which might impact the assessment of apoptotic and cognitive functions.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

the control group

No Intervention group

Description:

non-exercised participants with daily life activities

exercise group

Experimental group

Description:

participants engaged in a 12-week exercise regimen structured thrice weekly.Each session's intensity was customized to match the individual's maximum and resting heart rates. The warm-up involved stretching and a 5 to 10-minute walk. In the core exercise phase, participants aimed to reach their predetermined training heart rate (THR max; between 60 to 70%) for 45-60 minutes through intervals on a treadmill, bike, or stair climber.The exercise protocol was designed to elicit physical exertion equivalent to 30-45% of their maximum oxygen consumption (VO2 max)

Treatment:

Other: supervised aerobic exercise