Aerobic Exercise in Duchenne Muscular Dystrophy

Hacettepe University

Status: Completed

Conditions: Duchenne Muscular Dystrophy

Treatments: Other: Aerobic Training; Other: Home exercise program

Study type: Interventional

Funder types: Other

Identifiers

NCT04173234

KA-19022

Details and patient eligibility

About

Duchenne Muscular Dystrophy (DMD) is the most common neuromuscular disease in childhood with an estimate incidence of 1 in 3500 to 5000 male births. The effect of aerobic training on muscle architectural properties and motor functions such as muscle activation is not clear in DMD. The aim of this study is to investigate the effects of aerobic training on these parameters in children with DMD. Twenty children with DMD included in the study will be divided into two groups as home program and home program+aerobic training with block randomization method. Home program including stretching, respiratory, range of motion and mild resistance exercise with body weight will be asked to apply 3-5 days a week for 12 weeks, aerobic training will be performed 3 days a week for 12 weeks at 60% of their maximum hearth rate with 50 minutes total duration consisting of 10 min warm up and 10 min cool down period. Muscle architectural properties, muscle strength, muscle activation and motor function will be assessed with ultrasonographic, hand-held myometry, surface EMG and Motor Function Measure, consecutively. Assessments will be applied at pre-training and after 12 weeks of training.

Enrollment: 19 patients

Sex: Male

Ages: 5 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children had diagnosis of DMD confirmed by genetic analysis,
• Children had functional level of Grade 1 and 2 according to Vignos Scale.

Exclusion criteria

• Children had undergone any surgery or suffered injury of the lower limbs,
• Children had comorbid disease
• Children were applied regular aerobic training in last 6 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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19 participants in 2 patient groups

Treatment Group

Experimental group

Description:

Home exercise program Children will be given a home program including stretching, breathing, normal joint movement, body weight and mildly resistant exercises, and children will be asked to do these for 3 to 5 days a week. Also, aerobic training will be performed 3 days a week for 12 weeks at 60% of their maximum hearth rate with 50 minutes total duration consisting of 10 min warm up and 10 min cool down period to children in treatment group.

Treatment:

Other: Home exercise program

Other: Aerobic Training

Control Group

Active Comparator group

Description:

Home exercise program Children will be given a home program including stretching, breathing, normal joint movement, body weight and mildly resistant exercises, and children will be asked to do this program for 5 days a week.

Treatment:

Other: Home exercise program