Aerobic Exercise on Ventilatory Efficiency in CAD Patients

Hospital TotalCor

Status and phase: Completed; Phase 2

Conditions: Complication, Cardio-respiratory; Coronary Artery Disease; Exercise Addiction

Treatments: Other: Aerobic exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT02106533

53/2010

Details and patient eligibility

About

The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.

Full description

Measurements of ventilatory efficiency during cardiorespiratory exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs. In addition, a growing body of studies has demonstrated that lower ventilatory efficiency during exercise is considered an important predictor of risk mortality, hospitalization, and other outcomes than peak VO2.

Enrollment: 123 patients

Sex: All

Ages: 48 to 77 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• was stable coronary artery disease diagnosed by coronary angiography

Exclusion criteria

• unstable angina pectoris,
• complex ventricular arrhythmias,
• pulmonary congestion and
• orthopaedic or neurological limitations to exercise

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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123 participants in 3 patient groups

Group 1 peak VO2 <17.5 ml/kg/min

Experimental group

Description:

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP.

Treatment:

Other: Aerobic exercise training

Group 2 peak VO2 > 17.5 < 24.5 ml/kg/min

Experimental group

Description:

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Treatment:

Other: Aerobic exercise training

Group 3 peak VO2 > 24.5 ml/kg/min

Experimental group

Description:

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill . Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Treatment:

Other: Aerobic exercise training