Aerobic Interval Training in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypoxemia

Norwegian University of Science and Technology

Status: Completed

Conditions: Hypertension, Pulmonary; Pulmonary Disease, Chronic Obstructive; Hypoxia

Treatments: Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03092622

2013/2129

Details and patient eligibility

About

Patients with severe Chronic Obstructive Pulmonary Disease (COPD) and low oxygen levels in the blood are at risk of developing pulmonary hypertension and strain on the right side of the heart, both of which are known to increase symptoms and worsen prognosis It is not fully established whether interval exercise training in patients with severe COPD and concomitant low oxygen levels is beneficial.

This study aims to evaluate the effects of aerobic interval exercise training in patients with severe COPD and low oxygen levels in the blood, with a particular emphasis on such effects on the cardiovascular system and pulmonary circulation.

Enrollment: 16 patients

Sex: All

Ages: 45 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic Obstructive Pulmonary Disease (COPD)
• Forced Expiratory Volume 1 second (FEV1) <60% of predicted
• FEV1%FVC <70 % of predicted (FVC = Forced Vital Capacity)
• Qualify for Long term oxygen therapy (LTOT), or presence of significant desaturation on exercise.

Exclusion criteria

• Unstable ischaemic heart disease or valvular heart disease.
• Active malignant disease.
• Substance abuse.
• Physical or mental disability that prevents participation in the exercise programme or testing.
• Pregnancy.
• Exacerbation of COPD or respiratory tract infection last 6 weeks before.
• Completed pulmonary rehabilitation programme or other organised exercise programme last 3 month
• Use of high doses of systemic steroids.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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16 participants in 1 patient group

exercise training

Experimental group

Description:

Outpatients treadmill interval training, 4x4 minutes with 3 minutes in between at lower intensity. 3 sessions weekly for 10 weeks to a total of 30 sessions.

Treatment:

Other: Exercise