Aerobic Training, Aerobic-resistance Training and Glucose Profile (CGMS) in Type 2 Diabetes (CGMSexercise)

Hospital de Clinicas de Porto Alegre

Status: Completed

Conditions: Treatment; Diabetes Mellitus, Type 2; Exercise

Treatments: Behavioral: Acute aerobic-resistance exercise; Behavioral: Acute aerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT00887094

08-180

Details and patient eligibility

About

Many studies were already performed showing beneficial cardiovascular and metabolic effects of physical training for type 2 diabetic patients. However, glucose profile during and immediately after a short period of aerobic and/or resistance training was not studied yet. Continuous glucose monitoring system (CGMS) has now been added to the repertoire of technological devices useful in the management of patients with diabetes. Such monitoring enables clinicians to detect occult hypoglycemia and hyperglycemia not otherwise discernable with intermittent testing of blood glucose. The main aim of the present study is to investigate continuous blood glucose profile (using CGMS) over 72h, beginning 24h before and ending 24h after a single bout of aerobic or aerobic/resistance physical training in type 2 diabetic patients.

Full description

Many studies were already performed showing beneficial cardiovascular and metabolic effects of physical training for type 2 diabetic patients. However, glucose profile during and immediately after a short period of aerobic and/or resistance training was not studied yet. Continuous glucose monitoring system (CGMS) has now been added to the repertoire of technological devices useful in the management of patients with diabetes. Such monitoring enables clinicians to detect occult hypoglycemia and hyperglycemia not otherwise discernable with intermittent testing of blood glucose. The main aim of the present study is to investigate continuous blood glucose profile (using CGMS) over 72h, beginning 24h before and ending 24h after a single bout of aerobic or aerobic/resistance physical training in type 2 diabetic patients.

Enrollment: 14 patients

Sex: All

Ages: 35 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetic patients treated with diet and metformin, 35-65 years old

Exclusion criteria

• Type 1 diabetic patients
• Treatment with insulin or sulphonylureas or glitazones
• Proliferative retinopathy
• Severe autonomic neuropathy
• Coronary artery disease
• Baseline fasting plasma glucose>200 mg/dl
• Peripheral artery disease
• Amputation
• Heart failure
• Diabetic nephropathy
• Renal failure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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14 participants in 2 patient groups

Aerobic exercise

Experimental group

Description:

One bout of aerobic physical training will be performed on a cycle ergometer for 50 min

Treatment:

Behavioral: Acute aerobic exercise

Aerobic-resistance exercise

Experimental group

Description:

One bout of aerobic-resistance physical training will be performed on a cycle ergometer added by a strenght training for 50 min (total)

Treatment:

Behavioral: Acute aerobic-resistance exercise