Aerobic Versus Combined Exercise and Diastolic Dysfunction

Evangelismos Hospital

Status: Completed

Conditions: Diastolic Dysfunction; Heart Failure

Treatments: Other: aerobic exercise; Other: combined exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT04916184

43/28.03.2016

Details and patient eligibility

About

Thirty-two stable patients with chronic heart failure participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM). Before and after the program, they underwent a symptom-limited maximal cardiopulmonary exercise testing and serial echocardiography evaluation examining the indices of diastolic dysfunction (DD).

Full description

Thirty-two stable patients with chronic heart failure (age: 56 ± 10 years, EF: 32 ± 8%, 88 % men) participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM), based on age and peak oxygen uptake, as stratified randomization criteria. Before and after the program, they underwent a symptom-limited maximal cardiopulmonary exercise testing (CPET) and serial echocardiography assessment to evaluate peak oxygen uptake (VO2peak), peak workload (Wpeak), DD grade, right ventricular systolic pressure (RVSP) and EF.

Enrollment: 32 patients

Sex: All

Ages: 36 to 71 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic heart failure

Exclusion criteria

• atrial fibrillation COPD

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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32 participants in 2 patient groups

aerobic exercise

Active Comparator group

Description:

effects on diastolic dysfunction in patients with stable chronic heart failure

Treatment:

Other: combined exercise

Other: aerobic exercise

Combined exercise

Active Comparator group

Description:

effects on diastolic dysfunction in patients with stable chronic heart failure

Treatment:

Other: combined exercise

Other: aerobic exercise