Aerosol Delivery in Different Types of Nebulizers

Chang Gung University

Status: Completed

Conditions: Asthma

Treatments: Device: Breath enhanced nebulizer; Device: Breath-actuated nebulizer; Device: Manual-actuated nebulizer; Device: Constant jet nebulizer

Study type: Interventional

Funder types: Other

Identifiers

NCT02764307

ChangGungUniversity

Details and patient eligibility

About

Background: Nebulizers design influences efficiency of aerosol delivery. Performance of nebulizers is commonly tested by breathing simulators with static parameters. However, breathing patterns vary in adults.

Objectives: The purpose of this study was to evaluate drug deposition of different types of nebulizers testing with breathing patterns of healthy subjects.

Full description

Material and Methods

The study was approved by Chang Gung Memorial Foundation Institutional Review Broad. Ten healthy subjects, aged 20.6±0.5 years, were recruited. Four nebulizers:

1. a constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan);
2. a breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany);
3. a manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan); and
4. a breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) were evaluated.

Enrollment: 10 patients

Sex: All

Ages: 20 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy college subjects

Exclusion criteria

• Currently smoker
• History of asthma
• Drug allergy
• Pulmonary disease
• Heart disease
• Arrythmia
• Hyperthyroids
• Diabetes mellitus
• Lactacidosis
• Pregnant
• Under B-blocker medications

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

10 participants in 1 patient group

Aerosolized drug depositions

Experimental group

Description:

Aerosol drug deposited on the inhaled and exhaled filters and the residual dose were evaluated delivered by four types of nebulizer: 1) a constant jet nebulizer, a breath enhanced nebulizer, a manual-actuated nebulizer, and a breath-actuated nebulizer.

Treatment:

Device: Breath-actuated nebulizer

Device: Constant jet nebulizer

Device: Breath enhanced nebulizer

Device: Manual-actuated nebulizer