Aerosol Delivery in Different Types of Nebulizers

C

Chang Gung University

Status

Completed

Conditions

Asthma

Treatments

Device: Constant jet nebulizer
Device: Breath-actuated nebulizer
Device: Manual-actuated nebulizer
Device: Breath enhanced nebulizer

Study type

Interventional

Funder types

Other

Identifiers

NCT02764307
ChangGungUniversity

Details and patient eligibility

About

Background: Nebulizers design influences efficiency of aerosol delivery. Performance of nebulizers is commonly tested by breathing simulators with static parameters. However, breathing patterns vary in adults. Objectives: The purpose of this study was to evaluate drug deposition of different types of nebulizers testing with breathing patterns of healthy subjects.

Full description

Material and Methods The study was approved by Chang Gung Memorial Foundation Institutional Review Broad. Ten healthy subjects, aged 20.6±0.5 years, were recruited. Four nebulizers: a constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan); a breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany); a manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan); and a breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) were evaluated.

Enrollment

10 patients

Sex

All

Ages

20 to 25 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

* Healthy college subjects

Exclusion criteria

* Currently smoker * History of asthma * Drug allergy * Pulmonary disease * Heart disease * Arrythmia * Hyperthyroids * Diabetes mellitus * Lactacidosis * Pregnant * Under B-blocker medications

Trial design

Primary purpose

Health Services Research

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

Aerosolized drug depositions
Experimental group
Description:
Aerosol drug deposited on the inhaled and exhaled filters and the residual dose were evaluated delivered by four types of nebulizer: 1) a constant jet nebulizer, a breath enhanced nebulizer, a manual-actuated nebulizer, and a breath-actuated nebulizer.
Treatment:
Device: Breath enhanced nebulizer
Device: Manual-actuated nebulizer
Device: Breath-actuated nebulizer
Device: Constant jet nebulizer

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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