AFR10 - Combination Therapy of Imatinib Mesylate (IM) + Alpha-2A Interferon for Chronic Phase CML Patients Resistant or Refractory to IM Used as Single Therapy for at Least One Year

Civil Hospices of Lyon

Status and phase: Unknown; Phase 2

Conditions: Chronic Myeloid Leukemia

Treatments: Drug: Imatinib mesylate 600mg/day; Drug: Peg-Interféron at 90 microg/week

Study type: Interventional

Funder types: Other

Identifiers

NCT00146913

2003.317

Details and patient eligibility

About

Sixty % of CML patients treated by Imatinib mesylate achieved a major cytogenetic responses (CCR) at 18 months. So, 40% of the patients must receive additional treatment. In vitro, it has been shown that IM and Interféron-alpha have synergic anti-proliferative effect on chromosome Ph+ cell lines. By using Peg-Interféron and IM combination, we hope to increase the cytogenetic response of patients.

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic phase Philadelphia positive CML, confirmed by karyotyping (or FISH) analysis, in complete hematologic response with IM.
• Lack of major cytogenetic response after at least one year of STI 571 as single therapy.
• Male and female * 18 years old.
• Informed consent signed up.
• Performance status grade 0 - 2 (ECOG).
• SGOT and SGPT <3N
• Serum bilirubin < 1.5 N
• Serum creatinine < 1.5 N
• No HSC graft planned
• B-HCG negative for female with potential childbearing

Exclusion criteria

• Absence of complete hematologic response
• Extramedullar involvement
• Previous extra-hematologic intolerance of Interféron at a dose superior or equal to 25 MUI/week
• Depressive syndrome not controlled
• Not controlled dysthyroidy
• Auto-immune pathology not controlled
• Women with childbearing potential who are unwilling or unable to use an adequate method to avoid pregnancy for the entire period of the study
• Significant cardiac disease (grade 3 or more)
• Known seropositivity for HIV
• Active viral hepatitis
• Other malignant disease
• Other experimental medication