AG-858 in Patients Who Are Cytogenetically Positive After Treatment With Gleevec™

Agenus

Status and phase

Terminated

Phase 2

Conditions

Leukemia, Myeloid, Chronic

Treatments

Drug: Autologous HSP-70 Protein-Peptide Complex (AG-858) Plus Gleevec™.

Study type

Interventional

Funder types

Industry

Identifiers

NCT00058747

C-300-01

Details and patient eligibility

About

This is a Phase II, exploratory, open-label study of the investigational product AG-858, in patients who are cytogenetically positive after treatment with Gleevec.

The trial will consist of three independent Phase II evaluations of patient groups according to their cytogenetic status as defined in the eligibility criteria (Eligibility Criteria 4a, 4b, and 4c).

Full description

The goals of this study are to determine the following:

To estimate the proportion of patients with a complete cytogenetic response (CCR) within each patient group
To estimate the proportion of patients with a substantial molecular response (SMR) within each patient group
To evaluate the frequency and severity of adverse events.
To assess the feasibility of AG-858 production.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Must be Philadelphia chromosome positive chronic myelogenous leukemia in first chronic phase
Must have a complete hematologic response
Must have received Gleevec™, IFN-α, cytarabine, busulfan, hydroxyurea, Homoharringtonine (HHT) or any combination thereof as long as the combination has been discontinued and the dosing of Gleevec™ has been stable for 6 months or greater
Must have one of the following cytogenetic statuses:

(A) Less than a CCR after receiving Gleevec™ for at least one year at a minimum dose of 400 mg/day. A stable dose of Gleevec™ must have been maintained for the last six months prior to eligibility testing OR (B) Stable cytogenetic status without CCR (no cytogenic response or progression) in three consecutive determinations over six months while on a stable dose of Gleevec™ (at a minimum of 400mg/day) for at least 6 months OR (C) Cytogenetic progression while on a stable dose of Gleevec™ (at a minimum dose of 400mg/day)for at least 2 consecutive evaluations at least one month apart

ECOG performance score of 0 or 1
Must be at least 18 years old
Not pregnant or breastfeeding and agree to use contraception during the course of the study
No prior allogeneic bone marrow transplant or be candidates for curative BMT
No immunodeficiency or other serious illness
No current use of immunosuppressive medications
No other cancer within the last five years, with the exception of adequately treated cone-biopsied in situ carcinoma of the cervix uteri or basal or squamous cell carcinoma of the skin